Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interference and Diffraction02:18

Interference and Diffraction

52.5K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.5K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

4.8K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
4.8K
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

637
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
637
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

865
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
865
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

540
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
540
Atomic Structure01:33

Atomic Structure

210.0K
Overview
210.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Tuning of Ether Cosolvent Chemistry for High-Voltage Sodium-Ion Batteries.

Journal of the American Chemical Society·2026
Same author

Effect of Antagonistic Binder-Catalyst Interactions on Catalytic Activity in Lithium-Sulfur Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Chemomechanical Origin of Morphological Disparity in Lithium Metal Electrodeposition.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Impact of Anode to Cathode Crossover in Lithium-metal Batteries With High-Nickel Cathodes.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Modulating Li<sup>+</sup> and Polysulfide Solvation with Low-Density Moderately Solvating Electrolytes for Lithium-Sulfur Batteries.

Angewandte Chemie (International ed. in English)·2026
Same author

Tunable Crosslinked Ether Polymer Network Electrolytes for High-Performance All-Solid-State Sodium Batteries.

Small methods·2025

Related Experiment Video

Updated: Feb 4, 2026

In Situ Neutron Powder Diffraction Using Custom-made Lithium-ion Batteries
11:25

In Situ Neutron Powder Diffraction Using Custom-made Lithium-ion Batteries

Published on: November 10, 2014

16.3K

Extending the limits of powder diffraction analysis: Diffraction parameter space, occupancy defects, and atomic form

Liang Yin1, Gerard S Mattei1, Zhou Li1

  • 1Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, USA.

The Review of Scientific Instruments
|October 4, 2018
PubMed
Summary

Accurate site occupancy determination in layered NMC battery materials is challenging. New f* diagrams and combined neutron/synchrotron diffraction methods achieve 0.1% sensitivity for detecting defects and refining atomic form factors.

More Related Videos

Fourier-Based Diffraction Analysis of Live Caenorhabditis elegans
08:24

Fourier-Based Diffraction Analysis of Live Caenorhabditis elegans

Published on: September 13, 2017

8.3K
Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing
06:16

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing

Published on: April 25, 2019

8.0K

Related Experiment Videos

Last Updated: Feb 4, 2026

In Situ Neutron Powder Diffraction Using Custom-made Lithium-ion Batteries
11:25

In Situ Neutron Powder Diffraction Using Custom-made Lithium-ion Batteries

Published on: November 10, 2014

16.3K
Fourier-Based Diffraction Analysis of Live Caenorhabditis elegans
08:24

Fourier-Based Diffraction Analysis of Live Caenorhabditis elegans

Published on: September 13, 2017

8.3K
Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing
06:16

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing

Published on: April 25, 2019

8.0K

Area of Science:

  • Crystallography
  • Materials Science
  • Electrochemistry

Background:

  • Accurate determination of site occupancies is crucial in Rietveld refinement but is hindered by correlations and systematic errors.
  • Layered NMC (Li[NiₓMn<0xE1><0xB5><0xA7>Co₂]O₂) materials are vital Li-ion battery cathodes, where precise occupancy is key to performance.

Purpose of the Study:

  • To develop advanced methods for sensitive detection and accurate refinement of site occupancy defects in NMC materials.
  • To introduce and validate the utility of f* diagrams for analyzing crystallographic parameter space and identifying structural defects.

Main Methods:

  • Comparison of independently obtained neutron and synchrotron powder diffraction data.
  • Development and application of f* diagrams for visualizing diffraction parameter space and identifying structural minima.
  • Systematic investigation of atomic form factors, particularly for oxygen, in X-ray diffraction studies.

Main Results:

  • Achieved exceptional sensitivity of 0.1% (absolute) for detecting occupancy defects in NMC materials.
  • The f* diagram method successfully identified the global minimum fit and enabled robust determination of occupancy defects.
  • A systematic error in synchrotron results was identified and attributed to the neutral oxygen X-ray atomic form factor, resolvable by using the ionic O²⁻ form factor.

Conclusions:

  • The f* diagram method provides a robust tool for identifying occupancy defects and assessing structural quality in ternary compounds.
  • Combined neutron and X-ray diffraction, analyzed with f* diagrams, can reveal subtle errors in atomic form factors.
  • This work offers a new approach to experimentally validate atomic form factors in multi-component materials through powder diffraction.