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Preventive role of superoxide dismutase on radiation-induced periprosthetic capsule development
Didem Can Trabulus1, Ezgi Altinsoy1, Didem Karacetin2
1Istanbul Education and Training Hospital, General Surgery, Istanbul, Turkey.
Background:
Capsule fibrosis is the most important and annoying complication of breast implant surgery. Radiotherapy (RT) used in the local treatment of breast cancer has an increasing effect on the existing fibrous capsule; this is called radiation-induced fibrosis (RIF). In this randomized controlled experimental study, we aim to investigate the reduction effect of superoxide dismutase (SOD) on RIF.
Methods:
Sprague-Dawley rats were randomized into four groups, all of which were subjected to implant surgery. No additional procedures were done for the control group. The other groups were the SOD group, the RT + SOD group, and the RT group. The capsules were evaluated histopathologically.
Results:
Although SOD reduced surgery-induced capsule formation, it neither prevented nor reduced significantly RIF.
Conclusions:
In an experimental model that resembled breast cancer treatment, we concluded that SOD cannot reduce RIF but is effective in reducing capsular fibrosis around the silicone after implant surgery.
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