Related Experiment Video
Updated: Feb 4, 2026

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
Daptomycin for the treatment of Staphylococcus aureus infections complicated by septic pulmonary emboli
Ryan L Crass1, Kelsey L Powell2, Angela M Huang2
1Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Abstract:
The management of Staphylococcus aureus bacteremia is limited by high rates of methicillin resistance and the paucity of antibiotic agents with proven efficacy in complicated infectious syndromes, such as endocarditis. Vancomycin is the mainstay of therapy; however, salvage therapy is frequently required due to persistence of infection or drug toxicity. Daptomycin is FDA-approved for S. aureus bacteremia and right-sided endocarditis, but controversy exists regarding the role of this agent in the setting of septic pulmonary emboli. Sequestration by pulmonary surfactant renders daptomycin ineffective in bronchoalveolar pneumonia; however, the impact of this drug property on efficacy in hematogenous pulmonary infections is unclear. Herein we review the available evidence in order to inform the rationale use of daptomycin in S. aureus infections complicated by septic pulmonary emboli.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Hemodialysis II: Procedure and Complications
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...

