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Fully printed one-step biosensing device using graphene/AuNPs composite.

Bhawna Nagar1, Marc Balsells2, Alfredo de la Escosura-Muñiz2

  • 1Nanobioelectronics and Biosensors group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193 Barcelona, Spain; Novel Energy-Oriented Materials Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and The Barcelona Institute of Science and Technology, Campus UAB, Bellaterra, 08193 Barcelona, Spain.

Biosensors & Bioelectronics
|October 4, 2018
PubMed
Summary

A novel impedimetric sensor using reduced graphene oxide (rGO) and gold nanoparticles (AuNPs) enables one-step DNA detection. This printed biosensor offers a simple, cost-efficient platform for sensitive viral DNA identification.

Keywords:
BiosensingDNAElectrochemistryRGOScreen printingWax stamping

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Area of Science:

  • Materials Science
  • Biosensors
  • Nanotechnology

Background:

  • Growing demand for simple, cost-efficient, and flexible sensing systems.
  • Need for integrated and scalable biosensing platforms for diagnostics.

Purpose of the Study:

  • To design and fabricate a fully printed impedimetric sensor for one-step DNA detection.
  • To develop a cost-efficient and scalable biosensing platform using reduced graphene oxide (rGO) and gold nanoparticles (AuNPs).

Main Methods:

  • Fabrication of a DNA sensor using layered rGO and rGO/AuNPs/ssDNA composites on PET substrates via wax-printing.
  • Screen-printing of counter and reference electrodes for a compact sensing platform.
  • Utilizing electrochemical impedance spectroscopy (EIS) to monitor changes in electron transfer resistance.

Main Results:

  • Demonstrated a linear response for DNA hybridization detection in the concentration range of 0.01–20 µM.
  • Successfully detected target single-stranded DNA (ssDNA) specific to Coxsackie B3 virus.
  • Developed a novel, simple, and straightforward one-step printing process for biosensor fabrication.

Conclusions:

  • The developed printed rGO-based impedimetric sensor is a promising platform for one-step electrochemical DNA detection.
  • The fabrication process is suitable for large-scale manufacturing and can be extended to other affinity biosensors.
  • This integrated biosensing device offers a ready-to-use solution for sensitive and efficient DNA hybridization monitoring.