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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

The interaction of retrovirus and chemical carcinogen in experimental colon carcinogenesis

R L Nelson, W Wilson, S L Samelson

    Surgery
    |February 1, 1987
    PubMed

    Insights

    This study shows that Moloney murine sarcoma virus (MSV-M) infection enhances 1,2-dimethylhydrazine (DMH)-induced colon cancer in rats. Viral exposure significantly increased tumor development, suggesting a role for exogenous viruses in carcinogenesis.

    Area of Science:

    • Oncology
    • Virology
    • Gastroenterology

    Background:

    • Oncogenes in human colon cancer show homology to the ras gene in murine sarcoma virus (MSV).
    • Investigating the role of exogenous viruses in chemically induced cancers is crucial.

    Purpose of the Study:

    • To determine the effect of Moloney murine sarcoma virus (MSV-M) on 1,2-dimethylhydrazine (DMH)-induced colon carcinoma in rats.

    Main Methods:

    • Rats were treated with DMH weekly for 10 weeks.
    • MSV-M was administered either after the last DMH injection or before the first DMH injection.
    • Tumor incidence was compared between groups receiving DMH alone, DMH plus MSV-M, MSV-M alone, and untreated controls.

    Main Results:

    • Both late and pre-treatment with MSV-M significantly augmented colon tumor induction compared to DMH alone (p<0.05 and p<0.005, respectively).
    • Tumors were adenocarcinomas, characteristic of DMH induction, not MSV-M.
    • MSV-M alone or no treatment resulted in no tumors.

    Conclusions:

    • Exogenous viral infection, specifically MSV-M, plays a significant role in enhancing chemically induced colonic carcinogenesis.
    • This is the first study to demonstrate the importance of exogenous viral infection in DMH-induced colon cancer.

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