Related Experiment Video

Updated: Feb 4, 2026

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet
13:09

Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet

Published on: July 31, 2021

4.1K

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Hiroko Nakayama1, Yasuhito Shimada2,3,4, Liqing Zang5

  • 1Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan. 27293301@m.mie-u.ac.jp.

Nutrients
|October 4, 2018
PubMed

Insights

Red seaweed Palmaria mollis (PM) shows anti-obesity effects by improving lipid profiles and reducing fat accumulation. This functional food may help prevent obesity and related diseases.

Area of Science:

  • Marine biotechnology
  • Nutritional science
  • Obesity research

Background:

  • Palmaria mollis (PM), a red seaweed with a savory taste, is gaining popularity in Western diets.
  • Obesity is a growing global health concern with complex metabolic consequences.

Purpose of the Study:

  • To investigate the anti-obesity potential of Palmaria mollis.
  • To evaluate the effects of PM on diet-induced obesity (DIO) in zebrafish and mice models.

Main Methods:

  • Administration of PM-containing feed to DIO zebrafish and mice.
  • Assessment of anti-obesity effects, including lipid profiles and adiposity.
  • Analysis of gene expression in liver and visceral adipose tissues (VAT).

Main Results:

  • PM ameliorated dyslipidemia, hepatic steatosis, and visceral adiposity in both animal models.
  • PM modulated gene expression related to lipid metabolism in the liver, upregulating PPARA and downregulating PPARG pathways.
  • PM affected adipocyte differentiation genes in zebrafish VAT, but not in mice.

Conclusions:

  • Palmaria mollis demonstrated efficacy in preventing hepatic steatosis and visceral adiposity.
  • Dietary PM shows promise as a functional food for obesity prevention and mitigating obesity-related diseases.
Keywords:
adipogenesisanimal modelcomparative genomicsmetabolic syndrome

More Related Videos

Isolation and Characterization of Neutrophils with Anti-Tumor Properties10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

25.5K
Self-Administration of Drugs in Mouse Models of Feeding and Obesity03:37

Self-Administration of Drugs in Mouse Models of Feeding and Obesity

Published on: June 8, 2021

5.2K

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.3K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
265
Physical and Chemical Properties of Matter02:57

Physical and Chemical Properties of Matter

The characteristics that enable us to distinguish one substance from another are called properties.
166.5K
Properties of Transition Metals02:58

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.9K
General Properties of Solutions02:12

General Properties of Solutions

Many common substances around us exist as a solution, such as ocean water, air, and gasoline. All solutions are mixtures of substances that are composed of varying amounts of two or more types of atoms or molecules. A mixture with a non-uniform composition is a heterogeneous mixture, whereas a mixture with a uniform composition is a homogeneous mixture. The components that make the homogeneous mixture are evenly spread out and thoroughly mixed. 
35.8K
Convolution Properties I01:20

Convolution Properties I

Convolution computations can be simplified by utilizing their inherent properties.
The commutative property reveals that the input and the impulse response of an LTI (Linear Time-Invariant) system can be interchanged without affecting the output:
606