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Computerised Dynamic Posturography in Premanifest and Manifest individuals with Huntington's Disease
Alvaro Reyes1, Danielle Salomonczyk2, Wei-Peng Teo3
1Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile.
Scientific Reports
|October 4, 2018
Summary
Huntington
Area of Science:
- Neurology
- Movement Disorders
- Biomedical Engineering
Background:
- Huntington's disease (HD) is a neurodegenerative disorder.
- Postural instability is an early and disabling symptom of HD.
- Current research needs larger studies to validate postural stability as a clinical endpoint.
Purpose of the Study:
- To evaluate static and dynamic postural stability in individuals with premanifest and manifest Huntington's disease (HD).
- To assess the suitability of postural stability measures as clinical endpoints for HD clinical trials.
Main Methods:
- Utilized the Sensory Organization Test (SOT) and Limits of Stability (LOS) test.
- Assessed 54 premanifest HD, 36 manifest HD, and 45 healthy individuals.
- Analyzed static and dynamic postural stability parameters.
Main Results:
- Manifest HD patients showed significantly lower SOT scores and more falls than controls.
- Both premanifest and manifest HD groups exhibited impaired LOS measures, including endpoint excursion and directional control.
- Left-sided LOS deficits were observed in premanifest HD.
Conclusions:
- Individuals with premanifest and manifest HD exhibit significant static and dynamic postural instability.
- Dynamic posturography assessments are recommended as clinical endpoints for future HD trials.