Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
What is Metabolism?00:52

What is Metabolism?

131.9K
Overview
131.9K
Alterations in Respiration II01:30

Alterations in Respiration II

1.8K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.8K
Altered States of Awareness01:06

Altered States of Awareness

1.1K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.1K
Tumor Progression02:07

Tumor Progression

7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ARMC2 loss impairs cilia structure and leads to primary ciliary dyskinesia symptoms in mouse organs.

Frontiers in cell and developmental biology·2026
Same author

Sleep-like slow waves during resting-state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Automatic Extraction of PET RANO Criteria with an Externally Validated Deep Learning Model: Application to [18F]FDOPA PET Imaging.

Neuro-oncology·2026
Same author

[18F]FDG-PET/MRI Performance in Head-and-Neck Cancers at Initial Staging, Restaging and Follow Up.

AJNR. American journal of neuroradiology·2026
Same author

Iatrogenic Cerebral Amyloid Angiopathy After Cardiac Surgery: Two Case Reports.

Neurology·2026
Same author

18 F-DOPA PET Silence in High-grade Glioma Subtype F : A Distinct Metabolic Phenotype.

Clinical nuclear medicine·2026

Related Experiment Video

Updated: Feb 4, 2026

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography
05:53

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography

Published on: August 5, 2020

6.2K

Structural, Microstructural, and Metabolic Alterations in Primary Progressive Aphasia Variants.

Alexandre Routier1,2, Marie-Odile Habert3,4,5, Anne Bertrand2,6,7

  • 1Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, FrontLab, Paris, France.

Frontiers in Neurology
|October 4, 2018
PubMed
Summary

This study reveals distinct brain changes in primary progressive aphasia (PPA) variants using neuroimaging. Findings differentiate semantic, logopenic, and nonfluent/agrammatic PPA, aiding diagnosis and potential treatments.

Keywords:
MRIPETcortical metabolismcortical thicknessprimary progressive aphasiastracts

More Related Videos

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K
Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
08:48

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

12.8K

Related Experiment Videos

Last Updated: Feb 4, 2026

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography
05:53

Biomimetic Replication of Root Surface Microstructure using Alteration of Soft Lithography

Published on: August 5, 2020

6.2K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K
Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
08:48

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

12.8K

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Primary progressive aphasia (PPA) has distinct variants (semantic, logopenic, nonfluent/agrammatic) with varying brain alterations.
  • Previous studies often lacked multi-modal imaging to comprehensively assess these PPA variants.
  • Combining anatomical MRI, FDG-PET, and diffusion MRI is crucial for understanding PPA pathology.

Purpose of the Study:

  • To investigate and compare cortical, sub-cortical, and white matter tract alterations across early-stage PPA variants.
  • To integrate findings from T1 MRI, FDG-PET, and diffusion MRI to characterize atrophy, hypometabolism, and tract damage.
  • To identify distinct and overlapping neuroanatomical patterns associated with semantic, logopenic, and nonfluent/agrammatic PPA.

Main Methods:

  • Utilized a cohort of 86 early-stage PPA patients (semantic, logopenic, nonfluent/agrammatic) and 23 healthy controls.
  • Employed anatomical MRI for cortical thickness assessment.
  • Integrated FDG-PET for metabolism analysis and diffusion MRI for white matter tract integrity.

Main Results:

  • Semantic PPA: Showed anterior temporal atrophy/hypometabolism and affected tracts like the inferior longitudinal and uncinate fasciculi.
  • Logopenic PPA: Exhibited more extensive metabolic than atrophy changes in the temporo-parietal junction, with coherent tract alterations (superior/inferior longitudinal, inferior frontal-occipital fasciculi).
  • Nonfluent/Agrammatic PPA: Displayed frontal atrophy/hypometabolism (Broca's area affected metabolically) and damage to the uncinate fasciculus.

Conclusions:

  • Provided a robust, multi-modal neuroimaging characterization of early-stage PPA variants.
  • Highlighted overlapping temporal region damage in logopenic and semantic PPA, contrasting with distinct frontal involvement in nonfluent/agrammatic PPA.
  • Confirmed distinct anatomo-functional networks (frontal vs. temporal) vulnerable in different PPA subtypes, informing diagnostic and therapeutic strategies.