Related Experiment Video
Updated: Feb 4, 2026
10:08
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
16.5K
Ascending aortic dissection in a young patient using a synephrine-containing workout supplement
1Department of Internal Medicine, Kaiser Permanente Fontana Medical Center, Fontana, CA, USA.
Journal of Cardiology Cases
|October 4, 2018
Summary
A young patient experienced delayed diagnosis of aortic dissection after using a synephrine pre-workout supplement. This case highlights synephrine
Area of Science:
- Cardiovascular Medicine
- Medical Toxicology
Background:
- Aortic dissection in young individuals is rare and poses diagnostic challenges.
- Atypical presentations of ascending aortic dissection can lead to delayed diagnosis.
Observation:
- A patient presented with symptoms suggestive of aortic dissection following the use of a pre-workout supplement containing synephrine.
- Initial computed tomography imaging failed to diagnose the aortic dissection.
- Echocardiography successfully identified the ascending aortic dissection.
Findings:
- This is the first reported case of ascending aortic dissection associated with synephrine supplementation.
- The case suggests a potential link between synephrine and cardiovascular adverse events, specifically aortic dissection.
Implications:
- Highlights the diagnostic difficulties in atypical aortic dissection presentations.
- Underscores the potential cardiovascular risks associated with synephrine-containing supplements.
- Emphasizes the need for independent clinical trials to assess the safety of synephrine.
Related Concept Videos
01:15Aortic Regurgitation I: Introduction
634
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
634
01:25Aortic Regurgitation III: Medical Management
451
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
451
01:17Aortic Regurgitation IV: Nursing Management
322
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
322
01:13Patient-centered Care
3.0K
Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.0K
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
530
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
530
01:15Drug Dosing: Geriatric Patients
274
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
274