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Viral Sepsis in Children

Neha Gupta1, Robert Richter1, Stephen Robert2

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States.

Frontiers in Pediatrics
|October 4, 2018
PubMed

Insights

Viral sepsis in children is often overlooked, despite viruses being potential causes of culture-negative sepsis. Understanding viral sepsis is crucial for appropriate treatment and infection control.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Sepsis in children is often presumed bacterial, but cultures are frequently negative.
  • Viral pathogens are underrecognized causes of culture-negative sepsis globally.
  • The epidemiology, burden, and mortality of viral sepsis in children require further elucidation.

Purpose of the Study:

  • To review the current understanding of viral sepsis in children.
  • To address the epidemiology and pathophysiology of viral sepsis.
  • To outline clinical manifestations, diagnostics, and management specific to viral sepsis.

Main Methods:

  • Literature review of viral sepsis in pediatric populations.
  • Analysis of epidemiological data, pathophysiology, and host-pathogen interactions.
  • Synthesis of information on clinical presentation, diagnostic approaches, and therapeutic strategies.

Main Results:

  • Viral sepsis is a significant, yet poorly understood, contributor to pediatric sepsis.
  • Recognition of viral etiology impacts antibiotic use, infection control, and antiviral therapy.
  • Specific diagnostic and management considerations exist for viral sepsis.

Conclusions:

  • Viral sepsis in children is an important clinical entity that warrants greater attention.
  • Accurate diagnosis and timely management of viral sepsis can improve outcomes.
  • Further research is needed to fully characterize the impact of viral sepsis.
Keywords:
childrenpediatricsecondary bacterial infectionssepsisviral coinfectionsviral infectionsviral sepsis

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