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[Neurologic disorders in myeloma disease].

Iu S Martynov, E V Malkova, E I Sonina

    Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
    |January 1, 1986
    PubMed
    Summary

    Multiple myeloma frequently causes neurological disorders due to toxic-circulatory issues and mechanical spinal cord compression. Early medical intervention is crucial for managing these myeloma-related neurological complications.

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    Area of Science:

    • Neurology
    • Oncology
    • Pathophysiology

    Context:

    • Multiple myeloma is a hematologic malignancy affecting plasma cells.
    • Neurological complications are common in multiple myeloma patients.
    • Existing diagnostic methods for neurological disorders in myeloma are varied.

    Purpose:

    • To comprehensively examine neurological disorders in multiple myeloma patients.
    • To investigate the pathogenesis of neurological disturbances in myeloma.
    • To highlight the necessity of medicated correction for neurological issues.

    Summary:

    • A study of 120 myeloma patients utilized electroencephalography (EEG), rheoencephalography (REG), electromyography, and neurohistology.
    • Neurological disorders, including encephalopathy and neuropathic syndromes, were present in 91.7% of patients.
    • Pathogenesis involves toxico-dyscirculatory issues from plasmatic cell infiltration, dysproteinosis, kidney failure, and vertebral column deformation impacting the spinal cord.

    Impact:

    • Identifies a high prevalence of neurological disorders in multiple myeloma.
    • Elucidates the primary pathogenic mechanisms behind these neurological complications.
    • Underscores the critical need for timely and effective medical treatment for neurological disturbances in myeloma patients.

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