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Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

68.1K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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What is the Endocrine System?00:46

What is the Endocrine System?

420.7K
The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
420.7K
The Endocrine System01:29

The Endocrine System

1.4K
The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that...
1.4K
An Overview of the Endocrine System01:10

An Overview of the Endocrine System

14.2K
The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
The endocrine system collaborates...
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Structures of the Endocrine System00:59

Structures of the Endocrine System

12.1K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
12.1K
Chemical Signaling in the Endocrine System01:08

Chemical Signaling in the Endocrine System

7.3K
A signaling cascade is a series of events that facilitates the transmission of information within or between cells, culminating in a targeted response in the recipient cell. As chemical messengers, hormones are pivotal in initiating and modulating these intricate signaling cascades based on their solubility.
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
7.3K

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Updated: Feb 4, 2026

Methods to Test Endocrine Disruption in Drosophila melanogaster
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Methods to Test Endocrine Disruption in Drosophila melanogaster

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[Update on endocrine hypertension].

B Lechner1, D Heinrich2, S Nölting2

  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Innenstadt, Ziemssenstr. 1, 80336, München, Deutschland. benjamin.lechner@med.uni-muenchen.de.

Der Internist
|October 4, 2018
PubMed
Summary
This summary is machine-generated.

Secondary hypertension often stems from endocrine disorders. Recognizing key clinical signs and utilizing specific diagnostic tests aids in early detection and improved patient outcomes for these common conditions.

Keywords:
Cushing syndromeHypertension, secondaryParagangliomaPheochromocytomaPrimary aldosteronism

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Area of Science:

  • Endocrinology
  • Nephrology
  • Internal Medicine

Background:

  • Endocrine disorders are primary drivers of secondary hypertension.
  • Prompt diagnosis and targeted therapies are essential for better patient prognoses.
  • Identifying patients at risk for secondary hypertension is clinically significant.

Purpose of the Study:

  • To outline clinical indicators suggestive of secondary hypertension.
  • To detail essential diagnostic workups for suspected endocrine hypertension.
  • To guide the diagnostic and therapeutic pathways for secondary hypertension.

Main Methods:

  • Review of clinical constellations indicating increased risk for secondary hypertension.
  • Description of basic diagnostic laboratory tests: aldosterone-to-renin ratio, plasma metanephrines, and dexamethasone suppression test.
  • Emphasis on confirmatory testing, specialized referral, and adjunctive imaging.

Main Results:

  • Key risk indicators include spontaneous hypokalemia, early-onset hypertension, adrenal incidentaloma, and treatment-resistant hypertension.
  • Initial diagnostics involve aldosterone-to-renin ratio, free plasma metanephrines, and 1 mg dexamethasone suppression test.
  • Confirmatory testing and specialized consultation are crucial for borderline or persistent abnormal results.

Conclusions:

  • Clinical constellations can effectively identify patients at risk for secondary hypertension.
  • Standardized diagnostic testing is vital for confirming endocrine causes.
  • Tailored therapeutic strategies based on the specific endocrine disease are necessary.