Related Experiment Video

Updated: Feb 4, 2026

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

11.1K

Alterations in cerebral blood flow in children with congestive heart failure due to ventricular septal defect

Nurdan Ozturk Tasar1, Pelin Kosger2, Nevzat Uzuner3

  • 1Clinic of Pediatrics, Afyonkarahisar Sinanpasa State Hospital, Afyonkarahisar, Turkey.

Congenital Heart Disease
|October 4, 2018
PubMed

Insights

Heart failure treatment in children with ventricular septal defect (VSD) improved cerebral blood flow (CBF) velocities. Higher N-terminal pro-brain natriuretic peptide (NT-proBNP) levels correlated with lower CBF velocities, indicating hemodynamic impact.

Area of Science:

  • Pediatric Cardiology
  • Neurology
  • Medical Imaging

Background:

  • Ventricular septal defect (VSD) can lead to heart failure in children.
  • Cerebral blood flow (CBF) alterations may occur in children with VSD and heart failure.
  • The impact of heart failure treatment on CBF in these children is not fully understood.

Purpose of the Study:

  • To investigate the effect of VSD and heart failure on pediatric CBF.
  • To determine if heart failure treatment improves CBF in children with VSD.
  • To explore the relationship between CBF and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.

Main Methods:

  • Transcranial Doppler ultrasonography was used to assess CBF velocities and pulsatility indices in 40 children with VSD (13 with heart failure) and 25 healthy controls.
  • Measurements were repeated after heart failure treatment initiation.
  • Echocardiography evaluated cardiac structure, function, and pulmonary hypertension; correlations between echocardiographic and CBF parameters were analyzed.

Main Results:

  • CBF velocities did not significantly differ between VSD patients and controls initially.
  • Right and left maximum CBF velocities significantly increased posttreatment in children with VSD and heart failure.
  • Serum NT-proBNP levels were higher in children with VSD and heart failure and negatively correlated with CBF velocities.

Conclusions:

  • Heart failure treatment positively impacts CBF velocities in children with VSD.
  • Hemodynamic status in VSD with heart failure affects CBF.
  • NT-proBNP levels serve as a potential indicator related to CBF in this population.
Abstract

Keywords:
NT-proBNPcerebral blood flowchildrenheart failureventricular septal defect

More Related Videos

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

2.4K
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension09:23

Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

Published on: February 11, 2017

17.4K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
948
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.7K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
903
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.2K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
348
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
981