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[DISBIOTIC AND IMMUNOLOGICAL CHANGES OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS COMBINATION WITH

L E Smimova, E N Smirnova, E N Egorova

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |October 4, 2018
    PubMed

    Insights

    Chronic obstructive pulmonary disease (COPD) patients with arterial hypertension exhibit worsened dysbiosis and immune dysfunction. These changes correlate with the severity of hypertension, impacting cellular, humoral, and phagocytic immunity.

    Area of Science:

    • Immunology
    • Pulmonology
    • Microbiology

    Background:

    • Chronic obstructive pulmonary disease (COPD) is often comorbid with arterial hypertension.
    • The interplay between COPD, arterial hypertension, and immune system dysregulation requires further investigation.

    Purpose of the Study:

    • To investigate microflora and immune parameters in patients with COPD, differentiating between isolated COPD and COPD with arterial hypertension.
    • To assess the impact of hypertension severity on dysbiotic and immune profiles in COPD patients.

    Main Methods:

    • Evaluated fecal caseinolitic activity for dysbiosis.
    • Assessed immune status via leukogram, immunogram, CD3+, CD4+, CD8+, CD19+ cell levels, Ig A, Ig M, Ig G, and NST-test.
    • Compared immune and microflora indicators between COPD patients with and without hypertension, and across hypertension severity grades (I-III).

    Main Results:

    • COPD patients with arterial hypertension showed more pronounced dysbiosis and inflammatory syndrome compared to those with isolated COPD.
    • Weakened cellular immunity, heightened humoral immunity, and altered phagocytic immunity were observed in COPD patients with hypertension.
    • Dysbiotic and immune alterations intensified with increasing hypertension severity from grade I to III.

    Conclusions:

    • Arterial hypertension exacerbates dysbiosis and immune dysregulation in COPD patients.
    • Hypertension severity is directly associated with the degree of microfloral and immune system impairment in COPD.
    • Findings highlight the need for integrated management of COPD and arterial hypertension, considering immune and microfloral status.

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