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Updated: Feb 4, 2026

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.6K

Real-world use of PCSK9 inhibitors: A single-center experience

Sinan Sarsam1, Abeer Berry1, George Degheim1

  • 1Providence Providence-Park Hospitals, Department of Cardiology, Michigan State University (Southeast Campus), Southfield, MI, USA.

The Journal of International Medical Research
|October 4, 2018
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors significantly reduced LDL-C by 63% in patients with hyperlipidemia. These findings highlight PCSK9 inhibitors as effective add-on therapy for managing atherosclerotic cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Hyperlipidemia is a key risk factor for atherosclerotic cardiovascular disease (ASCVD).
  • Many patients exhibit statin intolerance or suboptimal response.
  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer an alternative for hyperlipidemia management.

Purpose of the Study:

  • To evaluate the real-world effectiveness of PCSK9 inhibitors in a cardiology practice.
  • To assess the impact of PCSK9 inhibitors on lipid profiles in patients with hyperlipidemia.

Main Methods:

  • Retrospective study involving 17 patients with heterozygous familial hypercholesterolemia or ASCVD.
  • Patients received maximally tolerated statins with additional PCSK9 inhibitor therapy.
  • Lipid profiles were compared at baseline and 4-6 weeks post-treatment initiation.

Main Results:

  • PCSK9 inhibitor treatment averaged 10.7 months.
  • Low-density lipoprotein cholesterol (LDL-C) decreased by 63% (154 to 57 mg/dL).
  • Total cholesterol reduced by 39%, triglycerides by 19.5%, and HDL-C increased by 10.7%.

Conclusions:

  • PCSK9 inhibitors demonstrate significant efficacy as add-on therapy to statins.
  • An approximate 63% reduction in LDL-C was observed.
  • PCSK9 inhibitors are a valuable option for patients with hyperlipidemia and high cardiovascular risk.
Abstract

Keywords:
DyslipidemiaLDL cholesterolPCSK9 inhibitoratherosclerotic cardiovascular diseaselipid-lowering therapystatin

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