Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spinal tuberculosis: proposed spinal infection multidisciplinary management project (SIMP) flow chart revision.

European review for medical and pharmacological sciences·2020

Same author

Prevalence of cervical HPV and attitude towards cervical screening in IBD patients under immunomodulatory treatment: a multidisciplinary management experience.

European review for medical and pharmacological sciences·2020

Same author

Editorial - "Spine-in-spine": few considerations regarding the so-called "Spinal transplant".

European review for medical and pharmacological sciences·2019

Same author

Minimal impact of lenvatinib (Lenvima®) on muscle mass in advanced hepatocellular carcinoma and implications for treatment duration. Two cases from the REFLECT study.

European review for medical and pharmacological sciences·2019

Same author

Laboratory handling practice for faecal microbiota transplantation.

Journal of applied microbiology·2019

Same author

Lack of association between Vitamin D status and free light chains profile with different chronic HCV-related liver and extrahepatic disorders.

European review for medical and pharmacological sciences·2019

Same journal

Retraction Note: Can the endometrioma be an obstacle to complete oocyte retrieval in IVF cycles? A retrospective study.

European review for medical and pharmacological sciences·2026

Same journal

Retraction Note: A multicenter clinical study with myo-inositol and alpha-lactalbumin in Mexican and Italian PCOS patients.

European review for medical and pharmacological sciences·2026

Same journal

Retraction Note: Oxycodone inhibits myocardial cell apoptosis after myocardial ischemia-reperfusion injury in rats via RhoA/ROCK1 signaling pathway.

European review for medical and pharmacological sciences·2026

Same journal

Intracoronary stem cell transplant in ischemic heart disease: a meta-analysis of randomized trials.

European review for medical and pharmacological sciences·2026

Same journal

From models to medicine: advanced preclinical systems and AI enabling RNA therapeutics in triple-negative breast cancer.

European review for medical and pharmacological sciences·2026

Same journal

Association of serum asprosin levels with obesity indices and metabolic parameters in adults.

European review for medical and pharmacological sciences·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

Production of IgG Fusion Proteins Transiently Expressed in Nicotiana benthamiana

Production of IgG Fusion Proteins Transiently Expressed in Nicotiana benthamiana

Published on: January 16, 2021

IgG cryoglobulinemia.

F Gulli¹, U Basile, L Gragnani

¹Clinical Pathology Laboratory, Ospedale Madre Giuseppina Vannini, Rome, Italy. umberto.basile@policlinicogemelli.it.

European Review for Medical and Pharmacological Sciences

|October 4, 2018

Summary

This summary is machine-generated.

Hepatitis C Virus (HCV)-associated Mixed Cryoglobulinemia involves IgG1 and IgG3 subclasses. This study suggests IgG3

More Related Videos

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Published on: July 13, 2017

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Published on: June 5, 2015

Related Experiment Videos

Last Updated: Feb 4, 2026

Production of IgG Fusion Proteins Transiently Expressed in Nicotiana benthamiana

Production of IgG Fusion Proteins Transiently Expressed in Nicotiana benthamiana

Published on: January 16, 2021

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Published on: July 13, 2017

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Published on: June 5, 2015

Area of Science:

Immunology
Virology
Neurology

Background:

Mixed Cryoglobulinemia (MC) is a significant extrahepatic manifestation associated with Hepatitis C Virus (HCV).
MC is characterized as an autoimmune and B-lymphoproliferative disorder.
Cryoglobulins (CGs) are classified into types based on immunoglobulin (Ig) composition, with Types II and III involving immune complexes with rheumatoid factor activity.

Purpose of the Study:

To investigate the role of specific IgG subclasses in the early stages of Hepatitis C Virus-associated Mixed Cryoglobulinemia.
To explore the association between IgG subclasses, rheumatoid factor activity, and neurological complications in HCV-positive patients.

Main Methods:

Case series analysis of six Hepatitis C Virus-positive patients presenting with peripheral neuropathy and transient ischemic attacks.
Cryoprecipitate analysis using immunofixation electrophoresis to determine IgG subclass composition (IgG1, IgG2, IgG3, IgG4).

Main Results:

All six patients exhibited cryoprecipitates composed of IgG1 and IgG3 subclasses with probable rheumatoid factor activity.
One patient presented with monoclonal IgG3 in their cerebrospinal fluid.
The findings support the hypothesis of IgG3 involvement in the initiation of CGs.

Conclusions:

The presence of IgG1 and IgG3 subclasses is a key immunochemical feature in this cohort of HCV-associated MC patients.
Hypothesizes that IgG passage across the blood-brain barrier, involving these subclasses, may contribute to transient ischemic attacks (TIAs) via intrathecal immune complex precipitation.