[COMORBIDITY AND POLYMORBIDITY IN ADULTS AND CHILDREN IN THE LIGHT OF THE PROBLEM OF NSAID-GASTROPATHY]

Area of Science:

• Pharmacology
• Gastroenterology
• Internal Medicine

Background:

• Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
• Their use is associated with significant risks, including gastropathy, especially in vulnerable populations.
• Understanding NSAID mechanisms and interactions is crucial for safe and effective patient management.

Purpose of the Study:

• To provide a comprehensive review of NSAID activity mechanisms, efficacy, and safety.
• To examine NSAID drug interactions in patients with co-morbid conditions across different age groups.
• To outline strategies for preventing NSAID-induced gastropathy and guide NSAID selection in complex therapeutic scenarios.

Main Methods:

• Systematic review of existing literature and data.
• Analysis of pharmacological properties and clinical data of NSAIDs.
• Evaluation of risk factors for adverse reactions and drug interactions.

Main Results:

• NSAIDs exhibit diverse activity mechanisms with varying effectiveness and safety profiles.
• Significant drug interactions and risks of NSAID-gastropathy exist, even with low doses.
• Individual patient characteristics, disease presentation, and risk factors are critical for NSAID selection.

Conclusions:

• Personalized NSAID selection and complex therapy are essential for optimizing treatment outcomes.
• Proactive prevention of NSAID-induced gastropathy is necessary.
• Clinicians must carefully consider patient-specific factors and drug properties to mitigate risks associated with NSAID use.