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Ileal perforation in the setting of atezolizumab immunotherapy for advanced bladder cancer

Jacqueline Zillioux1, Matthew DiLizia, Basil Schaheen

  • 1Department of Urology, University of Virginia, Charlottesville, Virginia, USA.

The Canadian Journal of Urology
|October 4, 2018
PubMed

Atezolizumab is a promising immunotherapy for advanced urothelial carcinoma. Like other immune checkpoint inhibitors, it can produce rare immune-related adverse events (IRAEs). Here we present the recent case of a patient with metastatic bladder cancer who developed diarrhea and abdominal pain months after beginning atezolizumab therapy. He presented to our institution with an ileal perforation secondary to atezolizumab-induced enterocolitis. After surgical repair, the patient's condition improved, and he was discharged. We discuss the management of atezolizumab-induced enterocolitis, including the importance of early recognition and intervention to prevent more devastating complications.

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