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Expanded haemodialysis: news from the field
Nans Florens1,2, Laurent Juillard1,2
1University of Lyon, CarMeN, INSERM U1060, INSA de Lyon, Université Claude Bernard Lyon 1, INRA U1397, Villeurbanne, France.
Summary
Expanded hemodialysis (HDx) using medium cut-off membranes shows promise for removing more toxins and improving patient well-being. Real-world use reported excellent tolerance with no adverse events, suggesting benefits for various conditions.
Area of Science:
- Nephrology
- Renal Replacement Therapy
Background:
- Expanded hemodialysis (HDx) utilizes medium cut-off membranes to enhance the clearance of uraemic toxins.
- Limited data exists on the real-world applications and benefits of HDx therapy.
Purpose of the Study:
- To evaluate the effectiveness and safety of HDx therapy in routine clinical practice.
- To explore potential benefits and applications of HDx for specific patient populations and conditions.
Main Methods:
- Analysis of feedback from the initial routine use of HDx therapy in European facilities.
- Review of 5191 HDx treatments to assess safety and identify potential patient benefits.
Main Results:
- Priming and rinse back procedures for HDx were rated as excellent.
- No adverse events were reported across 5191 HDx treatments.
- Potential benefits were observed for patients with itching, restless legs syndrome, asthenia, and malnourishment.
Conclusions:
- HDx therapy demonstrates excellent tolerance and safety in real-world settings.
- HDx shows promise for improving symptoms and nutritional status in specific patient groups.
- Further studies are warranted to explore HDx applications in myeloma, rhabdomyolysis, and cardiovascular diseases, with careful consideration in study design.
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