Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Implicit Differentiation01:25

Implicit Differentiation

55
In classical mechanics, motion is often described through relationships between spatial coordinates and time. A car moving along a straight highway with constant acceleration serves as a simple case where velocity is an explicit function of time. This scenario results in a linear equation, enabling straightforward analysis using basic differentiation techniques.In contrast, a satellite in circular orbit follows a path defined by an implicit function. The position of the satellite is constrained...
55
Logarithmic Differentiation01:28

Logarithmic Differentiation

65
When a car’s weight and driving forces act on a tire, they impose an external load on the rubber material. This load is resisted internally by forces distributed throughout the tire structure, which are defined as stress. The resulting deformation of the rubber due to this stress is quantified as strain. The relationship between stress and strain governs how the tire deforms under load and is central to understanding its mechanical response during operation.Rubber exhibits a nonlinear...
65
Cellular Differentiation00:57

Cellular Differentiation

5.4K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.4K
Differential Leveling01:12

Differential Leveling

718
Differential leveling is a precise method in surveying used to determine the elevation difference between two points. Its primary goal is to establish accurate vertical measurements to create level surfaces or grade lines critical for designing and constructing infrastructures such as roads, bridges, and buildings.The procedure for differential leveling begins with setting up and leveling the instrument at a point where the benchmark can be seen. The level rod is held on the benchmark (BM), and...
718
Integrator and Differentiator01:13

Integrator and Differentiator

1.5K
Op-amp circuits have significant applications in various fields, including automotive engineering. One such application is cruise control systems in cars, where op-amp circuits are integral for maintaining a constant speed. In these systems, op-amps function as both integrators and differentiators.
An integrator within an op-amp circuit produces an output directly proportional to the integral of the input signal. This is achieved by replacing the feedback resistor in a typical inverting...
1.5K
Differential Relays01:20

Differential Relays

776
Differential relays are used to protect generators, buses, and transformers by comparing electrical quantities at different points. When a fault occurs, the difference in current between the two points triggers the relay to operate, opening the circuit breaker. Under normal conditions, the current entering (i1) and leaving (i2) a generator are equal. When a fault occurs, however, these currents become unequal, and the difference current flows in the relay operating coil, causing the relay to...
776

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International perspectives on AI-driven pharmaceutical IP challenges.

Frontiers in digital health·2026
Same author

Initial validation of a pediatric cataplexy survey for children and adolescents with narcolepsy type 1.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Development of the pediatric narcolepsy patient-reported outcomes scale (PN-PROs).

Frontiers in sleep·2025
Same author

Barriers to Accessing Opioid Treatment in Rural Queensland: Perspectives From Consumers and Clinicians.

Drug and alcohol review·2025
Same author

Investigating the relationship between gut microbiota and electrocortical signatures of feedback processing: an ERP study.

Psychopharmacology·2025
Same author

Interoception, personality, and internet use: Preliminary insights into their association.

PloS one·2025

Related Experiment Video

Updated: Feb 4, 2026

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.4K

Dedifferentiated Liposarcoma With Myofibroblastic Differentiation.

Grace Y Wang, David R Lucas1

  • 1From the Department of Pathology, University of Michigan, Ann Arbor.

Archives of Pathology & Laboratory Medicine
|October 4, 2018
PubMed
Summary

Dedifferentiated liposarcoma, a diverse soft tissue tumor, can be misdiagnosed due to its myofibroblastic variant. Accurate diagnosis is crucial for appropriate prognosis and treatment, distinguishing it from mimics.

More Related Videos

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
06:02

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens

Published on: January 31, 2016

10.2K
Isolation of Myofibroblasts from Mouse and Human Esophagus
11:18

Isolation of Myofibroblasts from Mouse and Human Esophagus

Published on: January 18, 2015

11.6K

Related Experiment Videos

Last Updated: Feb 4, 2026

An Efficient Method to Obtain Dedifferentiated Fat Cells
06:11

An Efficient Method to Obtain Dedifferentiated Fat Cells

Published on: July 15, 2016

8.4K
Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
06:02

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens

Published on: January 31, 2016

10.2K
Isolation of Myofibroblasts from Mouse and Human Esophagus
11:18

Isolation of Myofibroblasts from Mouse and Human Esophagus

Published on: January 18, 2015

11.6K

Area of Science:

  • Oncology
  • Pathology
  • Soft Tissue Tumors

Background:

  • Liposarcoma encompasses several subtypes, with dedifferentiated liposarcoma exhibiting significant histomorphologic diversity.
  • A subset of dedifferentiated liposarcoma shows myofibroblastic differentiation, mimicking various benign and malignant soft tissue lesions.
  • Misdiagnosis of this variant can lead to adverse outcomes due to differing prognoses and treatments.

Purpose of the Study:

  • To review the clinicopathologic, immunohistochemical, and molecular characteristics of the myofibroblastic variant of dedifferentiated liposarcoma.
  • To highlight key features that distinguish this liposarcoma variant from its mimics.

Main Methods:

  • Literature review of major features and current understanding of dedifferentiated liposarcoma with myofibroblastic differentiation.

Main Results:

  • The myofibroblastic variant of dedifferentiated liposarcoma is an uncommon and underrecognized entity.
  • This variant shares similarities with reactive, benign, and malignant soft tissue lesions.
  • Past misdiagnoses include desmoid-type fibromatosis, inflammatory myofibroblastic tumor, and other sarcomas.

Conclusions:

  • The myofibroblastic variant of dedifferentiated liposarcoma presents diagnostic challenges.
  • Accurate differentiation from mimics is essential for appropriate patient management.
  • This underrecognized sarcoma may account for a significant proportion of aggressive retroperitoneal tumors previously misdiagnosed.