Related Experiment Video
Updated: Feb 4, 2026

Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Comparison of rate of tooth movement and pain perception during accelerated tooth movement associated with
Sonal Attri1, Rashmi Mittal1, Puneet Batra1
1a Department of Orthodontics and Dentofacial Orthopedics , Institute of Dental Studies and Technologies , Kadrabad, Modinagar , Uttar Pradesh , India.
Objectives:
To investigate the influence of micro-osteoperforation (MOP) on rate of orthodontic tooth movement and pain perception with fixed appliances.
Design:
2 arm parallel randomized controlled trial with an allocation ratio of 1:1.
Setting:
The outpatient department of a dental college.
Participants:
105 patients were screened, out of which 60 met the inclusion criteria and consented to participate; consisting of 33 females and 27 males requiring en-masse retraction following first premolar extractions.
Methods:
The experimental group consisted of patients bonded with a fixed appliance (Gemini 3M) who received MOP distal to canines throughout the period of retraction every 28 days. These were compared with a control group treated with identical brackets without MOP and were assessed for rate of tooth movement (canine retraction) and pain perception using a Visual Analogue Scale (VAS) of 10 mm.
Results:
Prior to commencement, all baseline parameters were matched between the two groups (p>0.05). A statistically significant increase in rate of tooth movement in the MOP group (p<0.05).
Conclusion:
MOP appears to enhance the rate of tooth movement with no differences in pain perception.
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