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Related Experiment Video

Updated: Feb 4, 2026

Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope
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Soft-Tissue Aberration Correction for Histotripsy.

Jonathan J Macoskey, Timothy L Hall, Jonathan R Sukovich

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |October 4, 2018
    PubMed
    Summary
    This summary is machine-generated.

    Acoustic cavitation emission shockwaves can correct therapeutic ultrasound aberrations in soft tissue. This novel method improves histotripsy treatment efficacy by overcoming sound speed variations, offering a potential in vivo solution.

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    Area of Science:

    • Medical Physics
    • Biomedical Engineering
    • Acoustic Imaging

    Background:

    • Histotripsy, a therapeutic ultrasound technique, faces challenges from acoustic aberrations caused by soft tissue heterogeneities.
    • These aberrations, mainly sound speed variations, lead to pulse defocusing and reduced treatment effectiveness.
    • Current aberration correction (AC) methods using hydrophones are impractical for in vivo applications.

    Purpose of the Study:

    • To investigate the feasibility of using acoustic cavitation emission (ACE) shockwaves as a point source for AC in histotripsy.
    • To evaluate the efficacy of ACE-based AC compared to traditional hydrophone AC methods.
    • To assess the impact of ACE AC on histotripsy array power requirements.

    Main Methods:

    • Utilized a 500-kHz, 112-element histotripsy phased array with transmit and receive capabilities to capture ACE shockwaves.
    • Characterized ACE shockwaves optically and acoustically, noting pressure increases with denser cavitation.
    • Tested hydrophone and ACE AC methods on ex vivo porcine abdominal tissue samples.

    Main Results:

    • Without AC, focal pressure decreased by 49.7% in abdominal tissue.
    • Hydrophone AC recovered 55.5% of the lost pressure.
    • ACE AC recovered over 20% of lost pressure and reduced required array power by ~31.5%.

    Conclusions:

    • ACE shockwaves from histotripsy-induced cavitation can serve as an effective point source for aberration correction.
    • The ACE AC method shows promise for improving histotripsy efficacy in soft tissues.
    • This approach offers a potential in vivo solution for aberration correction in therapeutic ultrasound.