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Published on: February 4, 2014
Association between antipsychotic medication and venous thromboembolism
1Newton Lodge Regional Secure Unit,Fieldhead Hospital,Wakefield WF1 3SP,England.
Objective:
This study aims to identify and review available evidence in the literature to determine the strength of association between antipsychotic medications and thromboembolism as an adverse effect.
Method:
Electronic databases were searched for evidence.
Results:
A total of 15 case reports, 14 case series, two observational studies and three case-control studies were found in the literature. Two case control studies found significantly increased risk of venous thromboembolism (OR 13.3 and 7.1 respectively). The risk was high for low potency antipsychotics. Studies were critically appraised to determine the strength of evidence.
Conclusion:
The studies reviewed indicate a significant association between antipsychotics and venous thromboembolism. Patients using the antipsychotics and those who prescribe them should be aware of this association.
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