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Related Concept Videos

Inflammation01:38

Inflammation

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Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

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Related Experiment Video

Updated: Jul 20, 2026

Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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Histopathology of vasculitis.

G Bajocchi1, A Cavazza

  • 1Rheumatology Unit, S. Maria Hospital - USL, IRCCS Institute, Reggio Emilia. gianluigi.bajocchi@ausl.re.it.

Reumatismo
|October 5, 2018
PubMed
Summary

Primitive vasculitis presents diverse pathologies that can appear similar histologically, complicating diagnosis. Comprehensive clinical assessment alongside histology is crucial for accurate identification and management of these complex vascular diseases.

Area of Science:

  • Rheumatology
  • Pathology
  • Internal Medicine

Background:

  • Primitive vasculitis encompasses a wide spectrum of complex pathologies.
  • Diverse forms of vasculitis can present with similar histological findings, irrespective of vessel size.
  • Clinical and histological presentations of vasculitis may not always align.

Purpose of the Study:

  • To review common forms of vasculitis encountered in clinical practice.
  • To guide clinicians in understanding the pathology of blood vessels affected by vasculitis.
  • To emphasize the importance of integrating clinical and histological data for diagnosis.

Main Methods:

  • Review of literature on primitive and systemic vasculitis.
  • Analysis of histological alterations in various vasculitis types.

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  • Correlation of clinical presentation with pathological findings.

    • Main Results:

    • Histological alterations in vasculitis can be non-specific and overlap across different types.
    • Histology is the gold standard but requires integration with clinical data.
    • Vasculitis histology evolves over time, influenced by disease activity and treatment.

    Conclusions:

    • Accurate vasculitis diagnosis necessitates a holistic approach combining clinical evaluation and histological analysis.
    • Clinicians must recognize the potential for overlapping histological features and temporal changes in vasculitis.
    • Understanding vessel pathology is key to managing diverse vasculitis presentations.