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[Oily chemoembolization of hepatoma]
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|February 1, 1987
Summary
Transcatheter oily chemoembolization (TOCE) with adriamycin-in-oil emulsion (AOE) and Lipiodol improves survival for unresectable hepatocellular carcinoma. This method offers a slow-release adriamycin effect and enhanced antitumor activity.
Area of Science:
- Hepatobiliary Medicine
- Interventional Radiology
- Oncology
Context:
- Hepatocellular carcinoma (HCC) is a primary liver cancer with limited treatment options for unresectable cases.
- Transcatheter oily chemoembolization (TOCE) is a palliative treatment modality for HCC.
Purpose:
- To evaluate the efficacy and survival outcomes of transcatheter oily chemoembolization (TOCE) using adriamycin-in-oil emulsion (AOE) and Lipiodol for unresectable hepatocellular carcinoma.
Summary:
- A study involving 100 patients with unresectable HCC treated with TOCE using adriamycin, Lipiodol, and Gelfoam was conducted.
- Adriamycin-in-oil emulsion (AOE) facilitated slow release of adriamycin, resulting in lower blood concentrations compared to single injections and higher tumor-specific concentrations.
- Cumulative survival rates at 6 months, 1 year, and 2 years were 81.9%, 53.8%, and 36.5%, respectively, showing improvement over embolization without Lipiodol.
Impact:
- TOCE with AOE and Lipiodol demonstrates a significant antitumor effect and improved survival rates in patients with unresectable HCC.
- The slow-release mechanism of adriamycin from AOE and the embolization effect of Gelfoam contribute to the treatment's efficacy.
- This technique offers a promising therapeutic strategy for managing unresectable hepatocellular carcinoma.