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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Correlation between Diabetes Mellitus and Knee Osteoarthritis: A Dry-To-Wet Lab Approach.

Navneet Kumar Dubey1,2, Dina Nur Anggraini Ningrum3,4,5, Rajni Dubey6

  • 1Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan. bioengineer.nkd@gmail.com.

International Journal of Molecular Sciences
|October 5, 2018
PubMed
Summary

Diabetes mellitus (DM) significantly increases the risk of knee osteoarthritis (KOA) in Taiwanese adults. This study found obesity is not a confounding factor for this association.

Keywords:
articular cartilagediabetes mellitusknee osteoarthritisodds ratioproteoglycanrisk

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Area of Science:

  • Endocrinology and Metabolic Diseases
  • Rheumatology and Orthopedics
  • Biochemistry

Background:

  • Diabetes mellitus (DM) and knee osteoarthritis (KOA) are increasingly prevalent, potentially sharing risk factors like obesity and aging.
  • Understanding the link between DM and KOA is crucial for public health and clinical management.

Purpose of the Study:

  • To investigate the association between type 1 DM (T1DM) and type 2 DM (T2DM) with KOA in the Taiwanese population.
  • To explore the role of obesity as a potential confounding factor in the DM-KOA relationship.

Main Methods:

  • A large-scale, population-based study using a phenome-wide association study portal.
  • Analysis of 37,353 T1DM and 1,218,254 T2DM patients.
  • Histopathological and Western blot analyses in diabetic mice models.

Main Results:

  • Significant associations were found between KOA and both T1DM (OR: 1.40) and T2DM (OR: 2.75).
  • Obesity did not significantly alter the T1DM-KOA association but showed a weaker link with KOA in T2DM patients compared to non-obese individuals.
  • Diabetic mice exhibited cartilage degradation, evidenced by increased advanced glycation end products and matrix metalloproteinase-1, and decreased cartilage-specific proteins.

Conclusions:

  • DM is strongly associated with an increased risk of KOA.
  • Obesity may not be a primary confounding factor for the DM-KOA association, particularly for T2DM.