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Cystic Fibrosis Mice Develop Spontaneous Chronic Bordetella Airway Infections

R Darrah1, T Bonfield2, J J LiPuma3

  • 1Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland Ohio, USA.

Journal of Infectious Pulmonary Diseases
|October 5, 2018
PubMed

Insights

Cystic fibrosis (CF) mice are more susceptible to Bordetella pseudohinzii infections and show reduced respiratory rates. This study highlights Bordetella

Area of Science:

  • Microbiology
  • Immunology
  • Pulmonology

Background:

  • Chronic pulmonary disease and infection are primary causes of morbidity and mortality in cystic fibrosis (CF).
  • Pseudomonas aeruginosa is the most common airway bacterium in CF, but the CF microbiome is diverse, including other taxa like Bordetella.
  • The role of Bordetella species in CF pathology is not well understood.

Purpose of the Study:

  • To identify and characterize Bordetella pseudohinzii infection in a CF mouse model.
  • To determine the impact of B. pseudohinzii infection on respiratory function and immune response in CF mice.
  • To establish the CF mouse model for studying CF-relevant infections.

Main Methods:

  • Infection of CF and non-CF mice with B. pseudohinzii.
  • Assessment of susceptibility and infection resolution.
  • Measurement of respiratory rates.
  • Analysis of CF-specific immune responses.

Main Results:

  • CF mice are more susceptible to B. pseudohinzii infection and less able to resolve it compared to non-CF mice.
  • B. pseudohinzii infection leads to markedly reduced respiratory rates in both CF and non-CF mice.
  • A CF-specific immune response was observed in infected mice.

Conclusions:

  • CF mice are a valuable model for studying B. pseudohinzii infections relevant to CF.
  • Bordetella species may contribute to the clinical pathology of cystic fibrosis.
  • Further research is needed to understand the full impact of Bordetella on CF lung disease.

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