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Structural and functional abnormalities in iron-depleted heart

Kamil A Kobak1, Malwina Radwańska1, Magdalena Dzięgała1

  • 1Laboratory for the Applied Research on Cardiovascular System, Department of Heart Diseases, Wroclaw Medical University, Wrocław, Poland.

Heart Failure Reviews
|October 5, 2018
PubMed

Insights

Iron deficiency (ID) in heart failure (HF) causes cardiac abnormalities. This review examines myocardial ID

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Iron Metabolism

Background:

  • Iron deficiency (ID) is a frequent comorbidity in heart failure (HF) and is linked to poorer patient outcomes, even without anemia.
  • Systemic ID has been associated with cardiac functional and structural changes in animal models.
  • The specific impact of myocardial iron deficiency, separate from systemic ID or anemia, remains unclear.

Purpose of the Study:

  • To investigate the influence of cardiac-specific iron deficiency on heart tissue.
  • To review the structural and functional cardiac consequences of ID in transgenic models.
  • To summarize clinical data and discuss the benefits of iron supplementation in HF.

Main Methods:

  • Review of existing literature on cardiac-specific iron deficiency models.
  • Analysis of data from transgenic animal models with targeted myocardial ID.
  • Synthesis of findings from relevant clinical studies.

Main Results:

  • Cardiac-specific ID models reveal distinct structural and functional cardiac abnormalities.
  • Myocardial ID contributes to cardiac dysfunction independently of systemic ID or anemia.
  • Clinical studies support the negative impact of ID on HF outcomes.

Conclusions:

  • Myocardial iron deficiency plays a significant role in the pathophysiology of heart failure.
  • Targeting myocardial iron deficiency may offer therapeutic benefits for heart failure patients.
  • Intravenous iron supplementation shows promise in improving outcomes for HF patients with ID.

Keywords:
Heart failureIron deficiencyIron supplementationMyocardial iron deficiency

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