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Updated: Feb 4, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Urgent Management of Obstructing Colorectal Cancer: Divert, Stent, or Resect?
Songphol Malakorn1,2, Sharon L Stein3, Jeffrey H Lee4
1Department of Surgical Oncology, Familial High-risk Gastrointestinal Cancer Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abstract:
Despite the availability of effective colorectal cancer (CRC) screening strategies, up to 10% of CRC patients present with obstructive symptoms as the first sign of disease. For patients with acute or subacute malignant obstruction that requires urgent intervention, treatment options include endoscopic stenting as a bridge to surgery, one-stage surgical resection and anastomosis, or diverting ostomy which may or may not be followed by later tumor resection and stoma closure. However, to date, there is no consensus guideline for the optimal approach to manage malignant colorectal obstruction. This article aims to illustrate clinical scenarios in palliative, curative, and potentially curative settings, and delineate the key factors to be considered when making an individualized decision in order to determine the optimal treatment.
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