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Related Experiment Videos

Activation of oncogenes by transposable elements.

D Givol

    Biochemical Society Symposium
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Repetitive DNA sequences in mammals can act as transposable elements, activating oncogenes. This study found mobile DNA insertions in mouse myeloma and canine tumors, leading to oncogene activation and cell transformation.

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    Area of Science:

    • Genetics
    • Molecular Biology
    • Cancer Research

    Background:

    • Mammalian DNA harbors highly repeated sequences, with some proposed as mobile elements.
    • Oncogene activation is implicated in tumor development.

    Purpose of the Study:

    • To investigate the role of repetitive DNA sequences as transposable elements in activating oncogenes within tumor tissues.
    • To analyze specific instances of oncogene rearrangement in mouse and canine tumors.

    Main Methods:

    • Screening of tumor tissues for oncogene rearrangement.
    • Analysis of DNA insertions using nucleotide sequencing.
    • Assessment of transcriptional activation and cell transformation capabilities of rearranged oncogenes.

    Main Results:

    Related Experiment Videos

    • Intracisternal A particle genome insertion into the c-mos gene in mouse myeloma NSI and XRPC24, leading to transcriptional activation and NIH 3T3 cell transformation.
    • Insertion of a 1.8 kilobase pair DNA element, homologous to the LINE family's KpnI element, into the c-myc gene in canine transmissible venereal tumor.
    • Demonstration of repetitive DNA elements functioning as transposable elements that can activate oncogenes.

    Conclusions:

    • Repetitive DNA sequences can act as mobile transposable elements in mammals.
    • Such mobile elements can insert into and activate oncogenes, contributing to tumorigenesis.
    • These findings highlight a mechanism for oncogene activation with implications for cancer development.