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Updated: Jul 31, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson's Disease-Relevant Phenotypes

S L Sison1, S C Vermilyea2,3, M E Emborg2,3,4

  • 1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, BSB 409, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.

Current Neurology and Neuroscience Reports
|October 5, 2018
PubMed
Summary

Induced pluripotent stem cells (iPSCs) model Parkinson's disease (PD) by retaining patient genetics and differentiating into neurons. This approach reveals common PD phenotypes like mitochondrial dysfunction and alpha-synuclein accumulation, aiding in understanding disease mechanisms and identifying therapeutic targets.

Keywords:
Alpha synucleinDopaminergic neuronsGene editingLRRK2MitochondriaOxidative stress

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