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Updated: Feb 4, 2026
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Fabrication and Characterization of Optical Tissue Phantoms Containing Macrostructure
Published on: February 12, 2018
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Multicenter reproducibility of quantitative susceptibility mapping in a gadolinium phantom using MEDI+0 automatic
Kofi Deh1, Keigo Kawaji2,3, Marjolein Bulk4,5
1Department of Radiology, Weill Medical College of Cornell University, New York, New York.
Magnetic Resonance in Medicine
|October 5, 2018
Summary
Quantitative susceptibility mapping (QSM) demonstrates excellent reproducibility across multiple sites and scanner vendors. This standardization is crucial for multicenter studies involving various susceptibility values in brain imaging.
Area of Science:
- Medical Imaging
- Biophysics
- Neuroimaging
Background:
- Quantitative susceptibility mapping (QSM) is a vital technique for measuring magnetic susceptibility in biological tissues.
- Standardization of QSM across different magnetic field strengths and scanner vendors is essential for multicenter research.
Purpose of the Study:
- To assess the reproducibility of QSM across multiple institutions and diverse scanner platforms (1.5T, 3T, 7T, 9.4T).
- To evaluate QSM standardization for multicenter studies using clinical and preclinical scanners from various vendors.
Main Methods:
- Seven phantoms with varying gadolinium concentrations were scanned on 12 clinical and 3 preclinical scanners.
- QSM was generated using Laplacian boundary value (LBV) and MEDI+0 algorithms.
- Reproducibility was analyzed using regression, Bland-Altman plots, and intra-class correlation coefficient (ICC).
Main Results:
- QSM images exhibited consistent, artifact-free quality across all scanners.
- A strong linear correlation (r² >0.99) was observed between gadolinium concentrations and QSM measurements.
- Excellent agreement was found, with an ICC of 0.991, indicating high measurement reproducibility.
Conclusions:
- QSM demonstrates robust multicenter reproducibility across a wide range of susceptibility values.
- The findings support the standardization of QSM for diverse applications in cranial and extra-cranial imaging.
- QSM is reliable on various scanner platforms, facilitating multicenter research.
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