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Updated: Feb 4, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
Investigation of the antimicrobial and anticancer activity of aminonaphthoquinones
Kevin W Wellington1, Natasha I Kolesnikova1, Nomgqibelo B P Nyoka2
1CSIR Biosciences, Pretoria, South Africa.
Abstract:
In this study, we report on the inhibitory activity of synthesized aminonaphthoquinones against two bacterial and one fungal species to determine their antimicrobial properties. A minimum inhibitory concentration (MIC) of 7.8 μg/mL was obtained against the fungus, Candida albicans, which was better than that of Amphotericin B (MIC = 31.25 μg/mL). Escherichia coli (Gram -), was inhibited at a MIC of 23.4 μg/mL and Staphylococcus aureus (Gram +) at a MIC of 31.3 μg/mL. The aminonaphthoquinones were also screened against HCT116 colon, PC3 prostate and HepG2 liver cancer cell lines to evaluate their cytostatic effects. They had potent activity (GI50 = 5.87-9.90 μM) which was about three-6-fold better than that of parthenolide (GI50 = 25.97 μM) against the prostate cancer cell line. These compounds were generally more selective for cancer cells than for normal human lung fetal fibroblasts (WI-38).
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