Dental hypomineralization treatment: A systematic review

Area of Science:

• Dentistry
• Biomaterials Science
• Regenerative Medicine

Background:

• Dental hypomineralization, including Molar-Incisor Hypomineralization (MIH), amelogenesis imperfecta, and dental fluorosis (DF), results from defects in enamel maturation leading to insufficient mineralization.
• These conditions are prevalent in dental practice, necessitating an analysis of effective treatment strategies.

Purpose of the Study:

• To systematically review and evaluate the effectiveness of various treatments for different forms of dental hypomineralization.

Main Methods:

• A comprehensive literature search was conducted across major databases (PubMed, Scopus, Cochrane Library, Web of Science, Embase) up to May 2018.
• Studies published in English, Spanish, and Portuguese were included, with methodology quality assessed using the Cochrane Handbook.

Main Results:

• Out of 7895 initial references, 33 studies were included in the systematic review.
• Reported treatments encompassed desensitizing/remineralizing products, resin infiltration, restorations, fissure sealants, tooth bleaching, enamel microabrasion, and nutritional supplements.
• Effective treatments identified include arginine pastes or fluoride varnishes for MIH and tooth bleaching and/or enamel microabrasion for DF.

Conclusions:

• While results are promising, a need for methodological uniformity exists to develop clinical guidelines for dental hypomineralization treatments.
• Specific effective treatments were identified for MIH and DF, offering guidance for clinical application.