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Amnion-Based Scaffold with Enhanced Strength and Biocompatibility for In Vivo Vascular Repair
Megan M Swim1, Ambra Albertario1, Dominga Iacobazzi1
1Bristol Heart Institute, Bristol Medical School, University of Bristol , Bristol, United Kingdom .
Impact Statement:
This study aimed at developing an amnion-based scaffold suitable for vascular tissue engineering applications and in vivo usage. We successfully produced a multilayered scaffold with improved biomechanical properties and biocompatibility for in vivo vascular implantation. Our approach not only offers an allogeneic "off-the-shelf" solution for clinical use but also it provides the possibility of personalized medicine using a patient's own amnion and stem cells for the production of tissue engineered grafts for reconstructive heart surgery.
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