Animal Models for Stem Cell-Based Pulp Regeneration: Foundation for Human Clinical Applications

Area of Science:

• Regenerative medicine
• Stem cell biology
• Dental research

Background:

• Animal models are crucial for studying tissue regeneration.
• Dental pulp regeneration research relies heavily on animal models.

Purpose of the Study:

• To review and discuss small and large animal models used in stem cell-mediated dental pulp regeneration.
• To categorize models based on regeneration site: ectopic, semiorthotopic, and orthotopic.

Main Methods:

• Literature review of studies utilizing animal models for dental pulp regeneration.
• Categorization of models based on implantation site and species.

Main Results:

• Identified mouse, ferret, dog, and miniswine as key animal models.
• Discussed the utility of ectopic, semiorthotopic, and orthotopic models.

Conclusions:

• The selection of appropriate animal models is vital for advancing mechanistic and translational studies in dental pulp regeneration.
• Further development and utilization of optimal models are critical for the field.