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[Experimental diabetes in mice infected with Coxsackie viruses]
Abstract:
The influence of Coxsackie B4 and AI3 viruses on the pancreas of mice (resistant and susceptible to diabetes) was studied. Glucose intolerance and changes in the synthesis of immunoreactive insulin were detected in all the treated groups of animals. Biochemical changes were more prominent in male DBA/2 mice, infected with Coxsackie B4 virus, in FI (CBA X C57Bl/6) hybrids and in female DBA/2 mice infected with Coxsackie AI3 virus and alloxan.
Insights
Coxsackie B4 and AI3 viruses impaired glucose metabolism and insulin synthesis in mice. These viral infections induced significant biochemical changes in the pancreas, particularly in susceptible mouse strains.
Area of Science:
- Virology
- Endocrinology
- Immunology
Background:
- Viral infections can affect pancreatic function and glucose homeostasis.
- Understanding the impact of specific viruses on diabetes susceptibility is crucial.
Purpose of the Study:
- To investigate the effects of Coxsackie B4 and AI3 viruses on pancreatic function in mice.
- To assess glucose intolerance and insulin synthesis changes following viral infection.
Main Methods:
- Mice (resistant and susceptible to diabetes) were infected with Coxsackie B4 and AI3 viruses.
- Glucose levels and insulin synthesis were monitored in infected animals.
- Biochemical changes in the pancreas were analyzed.
Main Results:
- All treated groups exhibited glucose intolerance and altered insulin synthesis.
- Male DBA/2 mice infected with Coxsackie B4 showed pronounced biochemical changes.
- FI hybrids and female DBA/2 mice infected with Coxsackie AI3 exhibited significant alterations.
Conclusions:
- Coxsackie B4 and AI3 viruses induce pancreatic dysfunction and metabolic disturbances in mice.
- Viral-induced pancreatic changes vary based on mouse strain and sex.
- These findings highlight the diabetogenic potential of certain enteroviruses.