Related Experiment Video
Updated: Feb 4, 2026

06:24
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
1.5K
Gender-Affirming Hormone Therapy for Transgender Men
1Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan.
Clinical Obstetrics and Gynecology
|October 5, 2018
Summary
Gender-affirming hormone therapy is crucial for transgender adults. Obstetricians and Gynecologists can improve access by offering testosterone protocols, which appear safe and effective for transgender men with proper monitoring.
Area of Science:
- Medical Science
- Endocrinology
- Public Health
Background:
- 1.4 million transgender adults in the US face healthcare access barriers.
- A significant barrier is the lack of providers knowledgeable in transgender care.
- Obstetricians and Gynecologists (OB/GYNs) can bridge this gap by offering gender-affirming hormone therapy.
Purpose of the Study:
- To assess the role of OB/GYNs in providing gender-affirming hormone therapy.
- To review testosterone protocols for transgender men.
- To evaluate the safety and effectiveness of testosterone therapy in transgender men.
Main Methods:
- Extrapolation of testosterone protocols from hypogonadal cisgender men.
- Review of available data on testosterone regimens for transgender men.
- Emphasis on proper screening and monitoring protocols.
Main Results:
- While high-quality, long-term studies are lacking, current data suggest testosterone therapy is safe and effective for transgender men.
- Existing protocols for cisgender men can be adapted for transgender men.
- Proper patient screening and ongoing monitoring are key to safe and effective treatment.
Conclusions:
- OB/GYNs are well-positioned to increase access to gender-affirming care.
- Competency in gender-affirming hormone therapy, specifically testosterone for transgender men, is essential.
- Available evidence supports the safety and efficacy of gender-affirming testosterone therapy when administered with appropriate oversight.
Related Concept Videos
Types of Hormones
83.6K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.6K
Types of Hormones
7.1K
Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
7.1K
Hormonal Regulation
36.1K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.1K
Hormonal Regulation
48.2K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.2K
Plant Hormones
27.6K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.6K
Socioemotional Experience and Gender Development
332
Social-emotional experiences and cultural influences play significant roles in shaping gender development. During middle childhood, from ages 6 to 11, peer groups become dominant in reinforcing gender norms. Children in this age group often align with same-gender peer groups, which actively encourage behaviors that conform to traditional gender roles. For instance, boys may be discouraged from engaging in activities perceived as feminine, reinforcing culturally dictated norms about masculinity...
332

