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Updated: Feb 4, 2026

A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening
Published on: October 16, 2015
A [11 C] CO dispensing system for rapid screening of carbonylation reactions
Berend Van der Wildt1, Bin Shen1, Frederick T Chin1
1Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Stanford University, School of Medicine, Stanford, California, USA.
Abstract:
[11 C] CO is a highly versatile synthon that allows for labeling at carbonyl positions of many molecules by means of transition metal-mediated carbonylation reactions. The intrinsic complexity of carbonylation reactions often requires tedious screening of reaction conditions for obtaining satisfying yields. Herein, a [11 C] CO dispending system for performing multiple reactions with a single batch of cyclotron-produced [11 C]CO2 is described. This semiautomated setup allows for more rapid and efficient screening of reactions and reaction conditions compared with the traditional "one beam for one reaction" strategy.
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