Granuloma multiforme: an uncommon differential for leprosy.
Shibani Bhatia1, Shrutakirthi D Shenoi2, Kanthilatha Pai3
11 Junior Resident, Department of Dermatology, Kasturba Medical College, Manipal, Karnataka, India.
Tropical Doctor
|October 6, 2018
Summary
Granuloma multiforme (GM) is a rare skin condition presenting as annular lesions. Early diagnosis is crucial as it can mimic leprosy, requiring histopathology for accurate identification.
Area of Science:
- Dermatology
- Pathology
Background:
- Granuloma multiforme (GM) is a chronic granulomatous skin condition.
- Clinically, it presents with annular lesions predominantly on sun-exposed areas.
- Histologically, it is characterized by focal necrobiosis and histiocytic granulomas.
Purpose of the Study:
- To report a case of Granuloma multiforme from India.
- To highlight the clinical presentation and diagnostic challenges of GM.
- To emphasize the importance of histopathology in differentiating GM from similar conditions.
Main Methods:
- Clinical case presentation of a 55-year-old female agriculturist.
- Detailed description of the patient's skin lesions.
- Histopathological examination for diagnosis.
Main Results:
- The patient presented with multiple asymptomatic large annular rings of papules on photo-distributed areas.
- Histopathology confirmed Granuloma multiforme.
- The diagnosis was differentiated from mimics like granuloma annulare and tuberculoid leprosy.
Conclusions:
- Granuloma multiforme requires a high index of suspicion for diagnosis.
- Histopathology is essential for confirming GM and distinguishing it from other annular skin conditions.
- GM should be considered in the differential diagnosis of various annular dermatoses.
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