Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induction

Induction

An emf is induced when the magnetic field in a coil is changed by pushing a bar magnet into or out of the coil. emfs of opposite signs are produced by motion in opposite directions, and the directions of emfs are also reversed by reversing poles. The same results are produced if the coil is moved rather than the magnet—it is the relative motion that is important. The faster the motion, the greater the emf. Additionally, there is no emf when the magnet is stationary relative to the coil.
A...

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...

Self-Inductance

Self-Inductance

Mutual inductance arises when a current in one circuit produces a changing magnetic field that induces an emf in another circuit. On the other hand, self-inductance arises when the current passing through the circuit changes, creating a changing magnetic flux, resulting in inductance in the same circuit.
Consider a circuit connected to an AC source. As the current varies with time, the magnetic flux through the circuit correspondingly changes. Faraday's law tells us that an emf would...

Mutual Inductance

Mutual Inductance

Inductance is the property of a device that tells us how effectively it induces an emf in another device. In other words, it is a physical quantity that expresses the effectiveness of a given device.
When two circuits carrying time-varying currents are close to one another, the magnetic flux through each circuit varies because of the changing current in the other circuit. Consequently, an emf is induced in each circuit by the changing current in the other. Therefore, this type of emf is called...

Inductive Reasoning

Inductive Reasoning

Inductive reasoning is a form of logical thinking that uses related observations to arrive at a general conclusion. It is uncertain and operates in degrees to which the conclusions are credible. As such, inductive arguments can be weak or strong, rather than valid or invalid, and conclusions can be used to formulate testable, falsifiable hypotheses.
Inductive reasoning is common in descriptive science. A life scientist makes observations and records them. This data can be qualitative or...

Air-entraining Agents

Air-entraining Agents

Air-entraining agents improve the durability and workability of concrete in climates with frequent freezing and thawing. These agents prevent cracks by introducing small air bubbles into the mix, creating spaces accommodating water expansion when temperatures drop. The air-entraining agents lower the surface tension of water, forming stable, small air bubbles. This method is more effective than having accidental large voids, as the intentional, smaller, and evenly distributed air voids improve...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Repurposing of Lidocaine for the Prevention and Treatment of Acute Lung Injury: An Integrative Review.

AANA journal·2025

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 4, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Etomidate as an Induction Agent in Sepsis.

Raymond J Devlin¹, David Kalil¹

¹Nurse Anesthesia Program, Louisiana State University Health Sciences Center, School of Nursing, 1900 Gravier Street, New Orleans, LA 70112, USA.

Critical Care Nursing Clinics of North America

|October 6, 2018

Summary

This summary is machine-generated.

Etomidate is commonly used for sedation during endotracheal intubation in sepsis patients. However, it causes adrenal insufficiency, sparking debate on its use in sepsis or septic shock.

Keywords:

Adrenal insufficiency Etomidate Mortality Rapid sequence induction Sepsis

More Related Videos

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Feb 4, 2026

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis

Published on: June 14, 2024

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

Critical care medicine
Pharmacology
Intensive care

Background:

Sepsis is a life-threatening infection response requiring endotracheal intubation in critically ill patients.
Etomidate is a common intravenous induction agent for sedation and amnesia prior to intubation.
Etomidate use is associated with predictable adrenal insufficiency.

Purpose of the Study:

To evaluate the ongoing controversy surrounding the use of etomidate in patients with sepsis or septic shock.
To analyze the implications of etomidate-induced adrenal insufficiency in septic patients.

Main Methods:

Literature review of studies on etomidate use in sepsis.
Analysis of clinical outcomes and adrenal function in patients receiving etomidate.
Discussion of current guidelines and expert opinions.

Main Results:

Etomidate reliably causes transient suppression of cortisol production.
The clinical significance of etomidate-induced adrenal insufficiency in sepsis is debated.
Alternative induction agents may be considered in specific septic patient populations.

Conclusions:

The use of etomidate in sepsis and septic shock remains controversial due to adrenal suppression.
Further research is needed to clarify the risks and benefits of etomidate in this population.
Careful consideration of patient-specific factors is essential when choosing an induction agent for intubation in sepsis.