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Adhesion01:14

Adhesion

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Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
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Cell Adhesion in Plants01:14

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Cell Adhesion Molecules - Types and Functions01:20

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
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The work done by a thermodynamic system depends not only on the initial and final states but also on the intermediate states—that is, on the path. Like work, when heat is added to a thermodynamic system, it undergoes a change of state, and the state attained depends on the path from the initial state to the final state. Consider an ideal gas cylinder fitted with a piston. When the cylinder is heated at a constant temperature, the gas molecules absorb energy and expand slowly in a...
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Thermal Expansion01:22

Thermal Expansion

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The expansion of alcohol in a thermometer is one of many commonly encountered examples of thermal expansion, which is the change in size or volume of a given system as its temperature changes. The most visible example is the expansion of hot air. When air is heated, it expands and becomes less dense than the surrounding air, which then exerts an upward force on the hot air to, for example, make steam and smoke rise, and hot air balloons float. The same behavior happens in all liquids and gases,...
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Multifunctional laminarin microparticles for cell adhesion and expansion.

C R Martins1, C A Custódio1, J F Mano1

  • 1Department of Chemistry, CICECO, Aveiro Institute of Materials, University of Aveiro Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

Carbohydrate Polymers
|October 6, 2018
PubMed
Summary

Researchers developed new microparticles for tissue engineering. These methacrylated laminarin microparticles support cell growth and self-assemble into 3D structures, advancing regenerative medicine.

Keywords:
Injectable scaffoldsMethacrylated laminarinMicrocarrierMicrofluidicMicrogelsPlatelet lysates

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Microfabrication is crucial for creating microgels used in tissue engineering.
  • Developing advanced microparticles is essential for functional constructs in regenerative medicine.

Purpose of the Study:

  • To develop multifunctional methacrylated laminarin microparticles using microfluidics and photopolymerization.
  • To investigate the impact of platelet lysates and adhesive peptides on cell behavior within these microparticles.
  • To assess the potential of these microparticles for creating 3D tissue constructs.

Main Methods:

  • Utilized microfluidics and UV-induced photopolymerization to synthesize methacrylated laminarin microparticles.
  • Loaded microparticles with platelet lysates and conjugated them with adhesive peptides.
  • Evaluated cell attachment, expansion, and self-assembly into 3D structures.

Main Results:

  • Achieved narrow size distribution in methacrylated laminarin microparticles.
  • Demonstrated enhanced cell adhesiveness and expansion with platelet lysate-loaded and peptide-conjugated microparticles.
  • Observed cell-mediated aggregation of microparticles into robust 3D structures.

Conclusions:

  • Methacrylated laminarin microparticles serve as effective supports for cell attachment and expansion.
  • Cell-driven assembly of microparticles offers a novel method for rapid construction of 3D tissue constructs.
  • These microplatforms hold significant potential for advancing tissue engineering and regenerative medicine.