Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

258
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
258
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

216
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
216
Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

360
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
360
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

329
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
329
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

302
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
302
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

451
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
451

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Graphene oxide-modified Ni<sub>1.5</sub>Mg<sub>1.5</sub>Al<sub>1</sub>-LDH/g-C<sub>3</sub>N<sub>4</sub> composites for efficient photocatalytic degradation toward ciprofloxacin.

Environmental research·2026
Same author

Completion of total mesorectal excision after total neoadjuvant therapy: Analysis of volume and approach in a contemporary National Cancer Database cohort.

Surgery·2026
Same author

Capturing static and dynamic dietary patterns for human gut microbiome research: a conceptual framework.

Gut microbes reports·2026
Same author

Neoadjuvant treatment response and oncologic outcomes after pelvic exenteration for locally advanced rectal cancer.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same author

Immunotherapy with guts: a review of microbial therapeutic adjuncts for immunotherapy in solid tumors.

The oncologist·2026
Same author

Watershed Fingerprints in Reservoir Sediments: Microeukaryotic Sedimentary DNA Tracks Decades of Anthropogenic Disturbance.

Molecular ecology·2026
Same journal

Fistulotomy with primary sphincteroplasty for complex anal fistulas: Should we be concerned about incontinence?

Surgery·2026
Same journal

No need for mesh in the repair of hiatal hernias: Autologous tissue hiatoplasty techniques for the repair of the complex diaphragmatic defect.

Surgery·2026
Same journal

Incretin-based therapies and altered myocardial metabolism in a swine model of ischemic heart disease in the setting of metabolic syndrome.

Surgery·2026
Same journal

Colonoscopy utilization and persistent disparities in early onset colorectal cancer: A multistate, multi-institution nested case-control study.

Surgery·2026
Same journal

From blades to heels: Lessons in performance from the ice to the practice of surgery.

Surgery·2026
Same journal

Preoperative risk assessment for surgical operations using artificial intelligence: Potential benefits, hurdles, and future directions.

Surgery·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.3K

Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management.

Cyrus Jahansouz1, Hongliang Xu2, Scott Kizy1

  • 1Department of Surgery, University of Minnesota, Minneapolis, MN.

Surgery
|October 6, 2018
PubMed
Summary
This summary is machine-generated.

Roux-en-Y gastric bypass significantly reduced fatty acid binding protein 4 (FABP4) in obese patients with type 2 diabetes mellitus after 12 months. Intensive lifestyle modification alone did not significantly alter FABP4 levels. Both adipose tissue types secreted FABP4 similarly.

More Related Videos

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

6.0K
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.7K

Related Experiment Videos

Last Updated: Feb 4, 2026

Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.3K
A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

6.0K
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.7K

Area of Science:

  • Endocrinology and Metabolism
  • Bariatric Surgery Research
  • Adipose Tissue Biology

Background:

  • Serum fatty acid binding protein 4 (FABP4) is linked to insulin resistance and cardiovascular risks.
  • FABP4 is an adipokine involved in fatty acid transport and metabolism.
  • Understanding FABP4's role in type 2 diabetes mellitus (T2DM) is crucial for metabolic health.

Purpose of the Study:

  • To investigate the impact of Roux-en-Y gastric bypass (RYGB) versus intensive lifestyle modification (ILM) on FABP4 in obese T2DM patients.
  • To assess the relationship between RYGB, ILM, FABP4, and metabolic parameters.
  • To determine the contribution of subcutaneous and visceral adipose tissue to FABP4 secretion.

Main Methods:

  • Randomized controlled trial comparing ILM with ILM plus RYGB in obese T2DM patients.
  • Measurement of serum FABP4 levels at baseline and 12 months post-intervention.
  • Analysis of adipose tissue explants to evaluate FABP4 secretion from different depots.

Main Results:

  • RYGB group showed a significant 42% decrease in serum FABP4 at 12 months (P=.002).
  • ILM group did not exhibit significant changes in serum FABP4.
  • Weight change did not predict FABP4 levels within or across treatment arms.
  • Adipose tissue explants demonstrated similar FABP4 secretion from subcutaneous and visceral depots.

Conclusions:

  • RYGB effectively reduces serum FABP4 levels in obese T2DM patients within 12 months.
  • ILM alone is insufficient to significantly alter FABP4 levels in this population.
  • FABP4 secretion is comparable between subcutaneous and visceral adipose tissue.