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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Alterations in Respiration II01:30

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There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
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Energy to Drive Translocation01:37

Energy to Drive Translocation

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Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
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Altered States of Awareness01:06

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Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
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Pulmonary Hypertension: Classification and Pathogenesis01:30

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Updated: Feb 4, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Genomic alterations driving psoriasis pathogenesis.

S Singh1, D Pradhan2, P Puri3

  • 1Biomedical Informatics Centre, National Institute of Pathology-ICMR, New Delhi 110029, India.

Gene
|October 6, 2018
PubMed
Summary
This summary is machine-generated.

Psoriasis is a complex inflammatory skin disease driven by genetic and environmental factors. Understanding these genetic alterations is key to developing personalized treatments for psoriasis patients.

Keywords:
AutoimmunityGenetic triggersIL23/Type 17 T cell axisKeratinocytesPSORS

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Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Background:

  • Psoriasis is an immune-mediated inflammatory skin disease.
  • Its etiology involves a complex interplay between environmental and genetic risk factors.
  • Genetic factors, including specific gene loci, copy number variations, and epigenetic alterations, are increasingly recognized in psoriasis pathogenesis.

Purpose of the Study:

  • To review and update the understanding of genomic alterations associated with psoriasis.
  • To explore the link between these genomic changes and the development of cutaneous inflammation in psoriasis.
  • To highlight the potential for personalized therapeutic strategies based on individual genetic profiles.

Main Methods:

  • Literature review of reported genomic alterations in psoriasis.
  • Analysis of genetic risk factors, differentially expressed genes, and deregulated proteins.
  • Examination of pathway-targeted therapeutics and their role in psoriasis pathogenesis.

Main Results:

  • Over 424 gene loci have been associated with psoriasis.
  • Copy number variations and epigenetic alterations are also implicated.
  • Genomic alterations contribute to the complex pathogenesis of psoriasis.

Conclusions:

  • Genomic alterations play a significant role in the development and progression of psoriasis.
  • Identifying specific genetic triggers in patients can facilitate personalized treatment approaches.
  • Further research into genomic factors is crucial for advancing psoriasis therapy.