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Related Concept Videos

Anorexia Nervosa01:28

Anorexia Nervosa

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Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
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Bulimia Nervosa01:30

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Initiation of Translation02:33

Initiation of Translation

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Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
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Sampling Methods: Overview01:06

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A sample refers to a smaller subset representative of a larger population. In analytical chemistry, studying or analyzing an entire population is often impractical or impossible. Therefore, samples are used to draw inferences and generalize the whole population. The sampling method selects individuals or items from a population to create a sample. Standard sampling methods include random, judgemental, systematic, stratified, and cluster sampling. 
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Transcription Initiation01:47

Transcription Initiation

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Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
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Related Experiment Video

Updated: Feb 4, 2026

Using the Activity-based Anorexia Rodent Model to Study the Neurobiological Basis of Anorexia Nervosa
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The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods.

Laura M Thornton1, Melissa A Munn-Chernoff1, Jessica H Baker1

  • 1University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Contemporary Clinical Trials
|October 6, 2018
PubMed
Summary

The Anorexia Nervosa Genetics Initiative (ANGI) successfully recruited over 13,000 individuals for genetic research using a multi-pronged approach. This study highlights the effectiveness of online recruitment for anorexia nervosa (AN) research.

Keywords:
Anorexia nervosaEating disordersGenome-wide associationPsychiatric geneticsPsychiatric genomics consortiumSocial media

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Area of Science:

  • Genetics
  • Psychiatry
  • Epidemiology

Background:

  • Genetic factors are implicated in anorexia nervosa (AN), with a significant genome-wide locus already identified.
  • The Anorexia Nervosa Genetics Initiative (ANGI) was established to accelerate genetic research in AN.
  • ANGI aimed to recruit a large cohort of individuals with AN and matched controls for genetic studies.

Purpose of the Study:

  • To describe the methods and procedures of the Anorexia Nervosa Genetics Initiative (ANGI).
  • To present sample characteristics and evaluate an online diagnostic questionnaire for eating disorders.
  • To assess the utility of the questionnaire for large-scale genetic and population research.

Main Methods:

  • ANGI employed a multi-pronged recruitment strategy across the US, Australia/New Zealand, Sweden, and Denmark.
  • Recruitment utilized national registers, treatment centers, and social/traditional media.
  • An online eating disorder questionnaire (ED100K-v1) was used for phenotyping, with its validity assessed against the Structured Clinical Interview for DSM-IV (SCID).

Main Results:

  • Blood samples and clinical data were collected from 13,363 individuals with AN and controls.
  • Online diagnostic phenotyping proved effective and efficient.
  • The ED100K-v1 questionnaire demonstrated acceptable validity for assessing AN.

Conclusions:

  • The ANGI's recruitment approach was highly effective for rapid cohort assembly and can serve as a model for future research.
  • Internet and social media were remarkably effective recruitment tools in certain countries due to the online presence of individuals with AN.
  • ANGI significantly contributed to the Psychiatric Genomics Consortium's AN sample collection and is a registered clinical trial.