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Models and methods for conditioning the ischemic brain.

Antonio Vinciguerra1, Ornella Cuomo1, Pasquale Cepparulo1

  • 1Division of Pharmacology, Department of Neuroscience, School of Medicine, "Federico II" University of Naples, Via Pansini, 5, 80131, Naples, Italy.

Journal of Neuroscience Methods
|October 6, 2018
PubMed
Summary
This summary is machine-generated.

Brain conditioning, including preconditioning and postconditioning, activates endogenous protective mechanisms against ischemic damage. Both methods offer comparable neuroprotection, with combined treatments showing no added benefit.

Keywords:
Brain ischemiaNeuroprotectionPostconditioningPreconditioningStroke

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cellular Biology

Background:

  • Investigating endogenous molecular mechanisms for neuroprotection.
  • Brain conditioning as an adaptive process conferring resistance to insults.
  • Preconditioning and postconditioning involve stimuli before or after ischemic events.

Purpose of the Study:

  • Review common methods for inducing brain conditioning.
  • Evaluate the efficacy of preconditioning and postconditioning strategies.
  • Identify potential neuroprotective targets.

Main Methods:

  • Surgical approaches
  • Physical exercise interventions
  • Temperature-induced conditioning
  • Pharmacological methods

Main Results:

  • Postconditioning provides neuroprotection comparable to preconditioning.
  • Combined preconditioning and postconditioning do not enhance protection.
  • Various methods effectively induce adaptive resistance in the brain.

Conclusions:

  • Understanding intrinsic cell-survival pathways is crucial for neuroprotection.
  • Examination of preconditioning and postconditioning models is essential for future research.
  • Translational neuroprotection trials can benefit from insights into conditioning mechanisms.