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Association of multiple primary melanomas with malignancy risk: A population-based analysis of entries from the

Emily D Cai1, Susan M Swetter2, Kavita Y Sarin1

  • 1Department of Dermatology, Stanford University Medical Center, Redwood City, California.

Journal of the American Academy of Dermatology
|October 6, 2018
PubMed
Abstract

Insights

Individuals with multiple primary melanomas (MPMs) face a higher risk of developing subsequent internal and cutaneous malignancies. Early cancer screening is recommended for these patients.

Area of Science:

  • Oncology
  • Dermatology
  • Epidemiology

Background:

  • Multiple primary melanomas (MPMs) are linked to genetic and environmental risk factors.
  • A hypothesis suggests MPM patients may have a higher incidence of internal malignancies.

Purpose of the Study:

  • To determine the risk of subsequent malignancies in patients diagnosed with multiple primary melanomas.

Main Methods:

  • Analysis of standardized incidence ratios for individuals with one or more primary melanomas (PMs).
  • Data sourced from the Surveillance, Epidemiology, and End Results database (1973-2014).

Main Results:

  • Increased risk of subsequent internal malignancies observed with a higher number of primary melanomas.
  • Higher incidence of internal malignancies noted in younger MPM patients and those with superficial spreading melanoma.
  • Significant increased risk for subsequent cutaneous melanoma in patients with multiple primary melanomas.

Conclusions:

  • Patients with multiple primary melanomas exhibit an elevated risk for both internal and cutaneous malignancies.
  • Adherence to age-specific cancer screening guidelines is crucial for individuals with MPMs.
Keywords:
SEERcancerdatabaseepidemiologymalignancymultiple primary melanomaspigmented lesionsstandardized incidence ratios

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