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Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals

Mohamed Elbadawy1,2, Tatsuya Usui3, Hideyuki Yamawaki4

  • 1Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan. mohamed.elbadawy@fvtm.bu.edu.eg.

International Journal of Molecular Sciences
|October 6, 2018
PubMed

Insights

Death associated protein kinases (DAPK) regulate cell death and are implicated in diseases. This review explores DAPK family roles, regulation, cross-talk with MAPKs, and therapeutic potential of DAPK inhibitors.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase.
  • The DAPK family includes DAPK1, DAPK2, DAPK3, and DRAK-1/DRAK-2.
  • DAPK family members play crucial roles in regulating programmed cell death.

Purpose of the Study:

  • To review the diverse roles and regulatory mechanisms of DAPK family members.
  • To highlight the involvement of DAPKs in various human diseases.
  • To examine the interplay between DAPKs and mitogen-activated protein kinases (MAPKs) in disease pathologies.

Main Methods:

  • Literature review of studies on DAPK family proteins.
  • Analysis of regulatory mechanisms and disease relevance.
  • Investigation of cross-talk between DAPKs and MAPKs.

Main Results:

  • DAPKs are key regulators of cell death pathways.
  • Dysregulation of DAPKs is linked to several human diseases.
  • Cross-talk between DAPKs and MAPKs influences disease progression.

Conclusions:

  • DAPK family members are critical regulators of cell death with significant implications in disease.
  • Understanding DAPK regulation and interactions, particularly with MAPKs, is vital.
  • Small molecule inhibitors targeting DAPKs show promise for therapeutic interventions in human diseases.
Keywords:
DAPKERKJNKMAPKp38

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