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Notch and interacting signalling pathways in cardiac development, disease, and regeneration

Donal MacGrogan1,2, Juliane Münch1,3,4, José Luis de la Pompa5,6

  • 1Intercellular Signalling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.

Nature Reviews. Cardiology
|October 6, 2018
PubMed

Insights

Notch signalling is vital for heart development, coordinating cell decisions and tissue formation. Disruptions in this pathway are linked to congenital heart diseases and impact heart repair.

Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Cell Signalling

Background:

  • Cardiogenesis involves intricate cell fate specification, proliferation, differentiation, and morphogenesis.
  • Intercellular signalling and tissue interactions are crucial for coordinating these developmental processes.
  • The Notch signalling pathway plays a key role in cell fate decisions during development.

Purpose of the Study:

  • To review the role of Notch signalling in cardiogenesis.
  • To examine Notch signalling crosstalk with other pathways during cardiac tissue differentiation and patterning.
  • To explore the link between Notch signalling perturbation and congenital heart diseases, as well as its role in cardiac repair.

Main Methods:

  • Literature review of studies on Notch signalling in heart development.
  • Analysis of research on cardiac valve and ventricular chamber development.
  • Examination of studies linking Notch signalling to congenital heart disease and cardiac regeneration.

Main Results:

  • Notch signalling is essential for progressive cell lineage restriction during cardiogenesis.
  • It coordinates differentiation and patterning of cardiac tissues, including valves and chambers.
  • Perturbations in Notch signalling are associated with congenital heart defects and influence heart repair mechanisms.

Conclusions:

  • Notch signalling is a critical regulator of cardiac development and patterning.
  • Its dysregulation contributes to congenital heart diseases.
  • Understanding Notch signalling offers potential for advancing heart regeneration and repair strategies.

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