The Quest for Materials-Based Hydrogels with Antimicrobial and Antiviral Potentialities

Area of Science:

• Biomedical Engineering
• Materials Science
• Infectious Diseases

Background:

• Antimicrobial resistance (AMR) and multidrug resistance (MDR) are escalating global health crises.
• Viral infections also pose significant and re-emerging threats worldwide.
• These issues are exacerbated by factors including increased antibiotic consumption and human behavior.

Purpose of the Study:

• To review the potential of biomaterials-based therapeutic hydrogels in addressing AMR/MDR and viral infections.
• To highlight the antimicrobial and antiviral properties of these advanced materials.
• To discuss the mechanisms of action and future research directions for hydrogel-based therapies.

Main Methods:

• Literature review focusing on hydrogels with antimicrobial and antiviral capabilities.
• Analysis of research exploring the application of biomaterials in drug delivery for infectious diseases.
• Discussion of biological mechanisms underlying hydrogel efficacy.

Main Results:

• Biomaterials-based hydrogels demonstrate significant potential for enhanced drug delivery.
• These hydrogels exhibit potent antimicrobial and antiviral activities.
• Understanding the mechanisms of action is crucial for optimizing therapeutic strategies.

Conclusions:

• Hydrogels represent a promising platform for developing novel treatments against resistant bacteria and viruses.
• Further research into hydrogel-based therapies is essential to combat the growing threat of AMR and viral infections.
• Interdisciplinary collaboration is key to advancing this field and improving global health outcomes.